Hillary Clinton on Friday brushed off Donald Trump's sometimes personal attacks against her as him being "off the reservation" -- something she said she has experience with.

"I have a lot of experience dealing with men who sometimes get off the reservation in the way they behave and how they speak," Clinton said in an interview with CNN's Jake Tapper, which first aired on "The Lead." The Democratic presidential front-runner did not elaborate which men she was referring to.

Tapper questioned Clinton about Trump's series of attacks on her, including nicknaming her "Crooked Hillary," saying she's only succeeding because she plays "the woman card" and insinuating about her personal life with tweets like one Friday that called her "one of the all time great enablers."

"I think the only card she has is the women's card," Trump said Tuesday night in New York. "She has got nothing else going. Frankly, if Hillary Clinton were a man, I don't think she would get 5% of the vote."