U.S. Senate Democrats on Wednesday failed to advance voting-rights legislation for the fourth time this year due to overwhelming Republican opposition, raising potential ramifications for the 2022 congressional and 2024 presidential elections.

The Senate voted 50-49 in favor of starting debate on the "John Lewis Voting Rights Advancement Act" but fell short of the 60 votes needed under a procedural blocking maneuver known as a filibuster. Named for the late civil rights activist and congressman, the legislation would restore state voting requirements to prohibit racial discrimination that were struck down by the U.S. Supreme Court in 2013.

Senator Lisa Murkowski was the only Republican out of 50 to vote with Democrats on advancing the voting rights bill.

Following the vote, Senate Majority Leader Chuck Schumer attacked the widespread use of filibusters by minority Republicans to stop Democratic legislation.

Possibly hinting at a change in Senate rules to circumvent the tactic, at least for some legislation, Schumer said: "We will continue to fight for voting rights and find an alternative path forward."

Democrats have made election reform a priority in light of Republican state-balloting restrictions passed in response to former President Donald Trump's false claims of massive voter fraud in the 2020 election. At least 19 states have passed laws making it harder to vote, according to the nonpartisan Brennan Center for Justice.